4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:主营:工程化抗体
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > Functional_antibody > 绝对抗体/抗DR5[PRO95780(卓齐单抗)]/50μg/Ab00740-21.0
商品详细绝对抗体/抗DR5[PRO95780(卓齐单抗)]/50μg/Ab00740-21.0
绝对抗体/抗DR5[PRO95780(卓齐单抗)]/50μg/Ab00740-21.0
绝对抗体/抗DR5[PRO95780(卓齐单抗)]/50μg/Ab00740-21.0
商品编号: Ab00740-21.0
品牌: absoluteantibody
市场价: ¥7200.00
美元价: 4320.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

UniProt Accession Number of Target Protein: O14763

Alternative Name(s) of Target: death receptor 5; TRAIL receptor 2; TRAILR2; tumor necrosis factor receptor superfamily member 10B; TNFRSF10B; CD262; apomabImmunogen: The variable domains of this antibody were derived as scFv from a human antibody phage display library, with biotinylated DR5-Fc used to capture DR5-specific phage. The scFv obtained were subsequently reformatted into full-length antibodies.

Specificity: This antibody is specific for human death receptor 5, a proapoptotic receptor widely expressed in adult and fetal tissues, with notably high expression on tumour cells. Activation of DR5 triggers apoptosis in various types of cancer cells, without affecting most normal cell types.

Application Notes: This antibody binds DR5, triggering DR5 clustering and DISC activation in a range of cancer cells, including colorectal cancer and NSCLC cells (Adams, 2009). Conversely, this antibody showed no effector caspase activation or cell death induction in normal human hepatocytes. In vivo, this antibody has been shown toinhibit tumor xenograft growth in a variety of animal models (Varfolomeev, 2009). This antibody was used in IP, immunoblot, ELISA and IF analysis to precisely characterise its interaction with the DR5 ligand (Adams, 2009).

Antibody first published in:Adams et al.Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5.Cell Death Differ. 2008 Apr;15(4):751-61PMID:18219321Note on publication:Describes the generation of this antibody from a phage display library, and subsequent characterisation of its binding specificity.

品牌介绍
Absolute antibody本公司服务于抗体测序、制造和工程服务提供给所有抗体使用者和不断增长的抗体。Absolute Antibody Ltd was founded in Oxford, UK, in August 2012, with the vision that all antibody users should be able to use recombinant antibodies, which are absolutely defined by their amino acid sequence. This view gained support in 2015 with a Comment in Nature magazine by Bradbury and Pluckthun (+110 co-signatories) – “Reproducibility: Standardize antibodies used in research“. Rather than creating entirely new antibodies (or antibody-like molecules), we are building a catalog by taking existing antibodies (often from hybridomas) then manufacturing them in a superior way and improving their usefulness by engineering.品牌货号名称规格absoluteantibody21 E11Anti-Api m 21 kitabsoluteantibodyBAB2Anti-Bet v 1 1 kitabsoluteantibodyBAB3Anti-Bet v 11 kitabsoluteantibodyBAB4Anti-Bet v 11 kitabsoluteantibodyBAB5Anti-Bet v 1 1 kitabsoluteantibodyBV16Anti-Bet v 1 1 kitabsoluteantibodyM0418Anti-Bet v 11 kitabsoluteantibody4C3Anti-Bla g 2 1 kitabsoluteantibody7C11Anti-Bla g 21 kitabsoluteantibodyD1Anti-Bos d 5 1 kitabsoluteantibody6A8Anti-Der f 11 kitabsoluteantibody10B9Anti-Der p 11 kitabsoluteantibody5H8Anti-Der p 11 kitabsoluteantibody4C1Anti-Neurotoxin AahII1 kitabsoluteantibodyH10Anti-Der p 21 kit