Description: Recombinant monoclonal antibody to ZIKV soluble envelope protein. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma z23.
Species and Isotype: Human IgG4-P, kappa
Clone Number: z23
UniProt Accession Number of Target Protein:
Published Application(s): Block
Published Species Reactivity: Zika virus
Immunogen: This antibody was derived from memory B cells specific for purified monomeric Zika virus soluble envelope protein, which were isolated by FACS from the blood of a patient 20 days post-infection with zika virus. To generate full-length monoclonal antibodies, the variable regions were then cloned into human IgG1 constant region.
Specificity: This antibody bind a tertiary epitope in the zika virus soluble envelope protein domain III.
Application Notes: This antibody specifically and potently neutralises Zika virus in vitro, and does not cross-react with strains 1 - 4 of dengue virus, which minimises the risk of antibody-dependent enhancement (Wang et al, 2016). In a murine model, this antibody confers postexposure protection against Zika virus (Wang et al, 2016).
Antibody First Published in:
Wang et al. Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus Science Translational Medicine, December 14, 2016, Vol.8(369), p.369ra179 Note on publication: Describes the original generation and characterisation of this antibody.

Product Form

Purification: Protein A affinity purified
Supplied in: PBS with preservative (0.02% Proclin 300)
Storage Recommendation: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C
Concentration: See vial label.