Description: Recombinant monoclonal antibody to IL-2R. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the therapeutic antibody Daclizumab. This antibody was created using our proprietary Fc Silent™ engineered Fc domain containing key point mutations that abrogate binding to Fc gamma receptors.
Species and Isotype: Human IgG1, Fc Silent™, kappa
Clone Number: Daclizumab
UniProt Accession Number of Target Protein: P01589
Alternative Name(s) of Target: Interleukin-2 receptor subunit alpha; IL-2 receptor subunit alpha; IL-2R subunit alpha; IL-2-RA; IL2-RA; TAC antigen; p55; CD25.
Published Application(s): FC; Block
Published Species Reactivity: Human; Rhesus Monkey; Cynomolgus Monkey
Immunogen: Cultured T-cells derived from a patient with Mycosis fungoides.
Specificity: Binds to p55 chain of IL2R on human T cells, Tac antigen, which is expressed on T cells activated by mitogens, soluble antigens, and alloantigens but not on resting T cells, thymocytes, B cells, monocytes, activated B cells, leukemic T cell blasts from patients with acute lymphoblastic leukemia, and long-term T cell lines.
Antibody First Published in:
Queen C, Schneider WP, Selick HE, Payne PW, Landolfi NF, Duncan JF, Avdalovic NM, Levitt M, Junghans R, Waldmann TA. A humanized antibody that binds to the interleukin 2 receptor. Proc Natl Acad Sci U S A. 1989 Dec;86(24):10029-33. PMID:2513570 Note on publication: Describes the preparation the humanised mouse anti human Tac monoclonal antibody by combining the CDRs of the mouse anti- Tac antibody with human framework and constant regions and affinity characterisation.

Product Form

Purification: Protein A affinity purified
Storage Recommendation: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C
Concentration: See vial label.