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当前位置: 首页 > 产品中心 > clinical_research > absoluteantibody/Ab00773-10.0 Anti-Lymphotoxin alpha [MLTA3698A (Pateclizumab)]/Ab00773-10.0/ 200 µg
商品详细absoluteantibody/Ab00773-10.0 Anti-Lymphotoxin alpha [MLTA3698A (Pateclizumab)]/Ab00773-10.0/ 200 µg
absoluteantibody/Ab00773-10.0 Anti-Lymphotoxin alpha [MLTA3698A (Pateclizumab)]/Ab00773-10.0/ 200 µg
absoluteantibody/Ab00773-10.0 Anti-Lymphotoxin alpha [MLTA3698A (Pateclizumab)]/Ab00773-10.0/ 200 µg
商品编号: Ab00773-10.0
品牌: absoluteantibody
市场价: ¥6384.00
美元价: 3830.40
产地: 美国(厂家直采)
公司:
产品分类: 临床研究
公司分类: clinical_research
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description:RecombinantmonoclonalantibodytoLymphotoxinalpha.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromthehybridomaMLTA3698A(Pateclizumab).
SpeciesandIsotype:HumanIgG1,kappa
CloneNumber:MLTA3698A(Pateclizumab)
UniProtAccessionNumberofTargetProtein:
PublishedApplication(s):FC;SPR;block;deplete
PublishedSpeciesReactivity:Human
Immunogen:Thishumanizedantibodywasderivedfromamouseanti-humanLT-ahybridomamAb.
Specificity:Thisantibodyisspecificforlymphotoxin-alpha,andisabletobindboththesolubleLTα3homotrimericformandthecell-surfaceLTα1β2heterotrimer,whichistransientlyexpressedonactivatedBandTcells(Th1,Th17).
ApplicationNotes:ThisantibodyhasbeenshowntoabletobothblockLTα-mediatedsignalingandselectivelydepleteLTα-expressingactivatedTandBcells,whichhastherapeuticapplicationsinabrogatingproinflammatoryresponsesinrheumatoidarthritis(RA)pathology(Kennedy,2014).PreliminaryclinicaltrialsdemonstratedthatadmiNISTrationofthisantibodydecreasedserumlevelsofCXCL13,abioMarkerofRAdiseaseactivity(Emu,2012).InaphaseIItrial,thisantibodyhadatrendforclinicaleffectsonthesymptomsofRAafter3monthsoftreatment,butthedifferencesfromplaceboresponseswerenotstatisticallysignificant(Kennedy,2014).InahumanperipheralbloodmononuclearcelltransplantedSCIDmousemodelofgraft-versus-hostdisease,thisantibodyspecificallydepletedactivatedLTα-expressinghumandonorTandBcells,prolongingsurvivalofthemice(Chiang,2012).Finally,thisantibodyhasbeenusedtoinFCandsurfaceplasmonresonanceanalysistocharacteriseitsinteractionwiththeLTαligand.
AntibodyFirstPublishedin:
Chiangetal.InVivoDepletionofLymphotoxin-AlphaExpressingLymphocytesInhibitsXenogeneicGraft-versus-Host-DiseasePLoSONE,2012,Vol.7(3),p.e33106PMID:22427961Noteonpublication:DescribesthegenerationofthisantibodyanditsuseinprolongingsurvivalinamousemodelofGVHD.

ProductForm

Purification:ProteinAaffinitypurified
Suppliedin:PBSwith0.02%Proclin300.
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.

Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals.
品牌介绍
Absolute antibody本公司服务于抗体测序、制造和工程服务提供给所有抗体使用者和不断增长的抗体。Absolute Antibody Ltd was founded in Oxford, UK, in August 2012, with the vision that all antibody users should be able to use recombinant antibodies, which are absolutely defined by their amino acid sequence. This view gained support in 2015 with a Comment in Nature magazine by Bradbury and Pluckthun (+110 co-signatories) – “Reproducibility: Standardize antibodies used in research“. Rather than creating entirely new antibodies (or antibody-like molecules), we are building a catalog by taking existing antibodies (often from hybridomas) then manufacturing them in a superior way and improving their usefulness by engineering.品牌货号名称规格absoluteantibody21 E11Anti-Api m 21 kitabsoluteantibodyBAB2Anti-Bet v 1 1 kitabsoluteantibodyBAB3Anti-Bet v 11 kitabsoluteantibodyBAB4Anti-Bet v 11 kitabsoluteantibodyBAB5Anti-Bet v 1 1 kitabsoluteantibodyBV16Anti-Bet v 1 1 kitabsoluteantibodyM0418Anti-Bet v 11 kitabsoluteantibody4C3Anti-Bla g 2 1 kitabsoluteantibody7C11Anti-Bla g 21 kitabsoluteantibodyD1Anti-Bos d 5 1 kitabsoluteantibody6A8Anti-Der f 11 kitabsoluteantibody10B9Anti-Der p 11 kitabsoluteantibody5H8Anti-Der p 11 kitabsoluteantibody4C1Anti-Neurotoxin AahII1 kitabsoluteantibodyH10Anti-Der p 21 kit