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absoluteantibody/Ab00773-10.0 Anti-Lymphotoxin alpha [MLTA3698A (Pateclizumab)]/Ab00773-10.0/ 200 µg
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absoluteantibody/Ab00773-10.0 Anti-Lymphotoxin alpha [MLTA3698A (Pateclizumab)]/Ab00773-10.0/ 200 µg
商品编号：
Ab00773-10.0
品牌：
absoluteantibody
市场价：
¥6384.00
美元价：
3830.40
产品分类：
临床研究
公司分类：
clinical_research
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:RecombinantmonoclonalantibodytoLymphotoxinalpha.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromthehybridomaMLTA3698A(Pateclizumab).
SpeciesandIsotype:HumanIgG1,kappa
CloneNumber:MLTA3698A(Pateclizumab)
UniProtAccessionNumberofTargetProtein:
PublishedApplication(s):FC;SPR;block;deplete
PublishedSpeciesReactivity:Human
Immunogen:Thishumanizedantibodywasderivedfromamouseanti-humanLT-ahybridomamAb.
Specificity:Thisantibodyisspecificforlymphotoxin-alpha,andisabletobindboththesolubleLTα3homotrimericformandthecell-surfaceLTα1β2heterotrimer,whichistransientlyexpressedonactivatedBandTcells(Th1,Th17).
ApplicationNotes:ThisantibodyhasbeenshowntoabletobothblockLTα-mediatedsignalingandselectivelydepleteLTα-expressingactivatedTandBcells,whichhastherapeuticapplicationsinabrogatingproinflammatoryresponsesinrheumatoidarthritis(RA)pathology(Kennedy,2014).PreliminaryclinicaltrialsdemonstratedthatadmiNISTrationofthisantibodydecreasedserumlevelsofCXCL13,abioMarkerofRAdiseaseactivity(Emu,2012).InaphaseIItrial,thisantibodyhadatrendforclinicaleffectsonthesymptomsofRAafter3monthsoftreatment,butthedifferencesfromplaceboresponseswerenotstatisticallysignificant(Kennedy,2014).InahumanperipheralbloodmononuclearcelltransplantedSCIDmousemodelofgraft-versus-hostdisease,thisantibodyspecificallydepletedactivatedLTα-expressinghumandonorTandBcells,prolongingsurvivalofthemice(Chiang,2012).Finally,thisantibodyhasbeenusedtoinFCandsurfaceplasmonresonanceanalysistocharacteriseitsinteractionwiththeLTαligand.
AntibodyFirstPublishedin:
Chiangetal.InVivoDepletionofLymphotoxin-AlphaExpressingLymphocytesInhibitsXenogeneicGraft-versus-Host-DiseasePLoSONE,2012,Vol.7(3),p.e33106PMID:22427961Noteonpublication:DescribesthegenerationofthisantibodyanditsuseinprolongingsurvivalinamousemodelofGVHD.
Concentration:Seeviallabel.
Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals.SpeciesandIsotype:HumanIgG1,kappa
CloneNumber:MLTA3698A(Pateclizumab)
UniProtAccessionNumberofTargetProtein:
PublishedApplication(s):FC;SPR;block;deplete
PublishedSpeciesReactivity:Human
Immunogen:Thishumanizedantibodywasderivedfromamouseanti-humanLT-ahybridomamAb.
Specificity:Thisantibodyisspecificforlymphotoxin-alpha,andisabletobindboththesolubleLTα3homotrimericformandthecell-surfaceLTα1β2heterotrimer,whichistransientlyexpressedonactivatedBandTcells(Th1,Th17).
ApplicationNotes:ThisantibodyhasbeenshowntoabletobothblockLTα-mediatedsignalingandselectivelydepleteLTα-expressingactivatedTandBcells,whichhastherapeuticapplicationsinabrogatingproinflammatoryresponsesinrheumatoidarthritis(RA)pathology(Kennedy,2014).PreliminaryclinicaltrialsdemonstratedthatadmiNISTrationofthisantibodydecreasedserumlevelsofCXCL13,abioMarkerofRAdiseaseactivity(Emu,2012).InaphaseIItrial,thisantibodyhadatrendforclinicaleffectsonthesymptomsofRAafter3monthsoftreatment,butthedifferencesfromplaceboresponseswerenotstatisticallysignificant(Kennedy,2014).InahumanperipheralbloodmononuclearcelltransplantedSCIDmousemodelofgraft-versus-hostdisease,thisantibodyspecificallydepletedactivatedLTα-expressinghumandonorTandBcells,prolongingsurvivalofthemice(Chiang,2012).Finally,thisantibodyhasbeenusedtoinFCandsurfaceplasmonresonanceanalysistocharacteriseitsinteractionwiththeLTαligand.
AntibodyFirstPublishedin:
Chiangetal.InVivoDepletionofLymphotoxin-AlphaExpressingLymphocytesInhibitsXenogeneicGraft-versus-Host-DiseasePLoSONE,2012,Vol.7(3),p.e33106PMID:22427961Noteonpublication:DescribesthegenerationofthisantibodyanditsuseinprolongingsurvivalinamousemodelofGVHD.
ProductForm
Purification:ProteinAaffinitypurifiedSuppliedin:PBSwith0.02%Proclin300.
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°CConcentration:Seeviallabel.
品牌介绍
Absolute antibody本公司服务于抗体测序、制造和工程服务提供给所有抗体使用者和不断增长的抗体。Absolute Antibody Ltd was founded in Oxford, UK, in August 2012, with the vision that all antibody users should be able to use recombinant antibodies, which are absolutely defined by their amino acid sequence. This view gained support in 2015 with a Comment in Nature magazine by Bradbury and Pluckthun (+110 co-signatories) – “Reproducibility: Standardize antibodies used in research“. Rather than creating entirely new antibodies (or antibody-like molecules), we are building a catalog by taking existing antibodies (often from hybridomas) then manufacturing them in a superior way and improving their usefulness by engineering.品牌货号名称规格absoluteantibody21 E11Anti-Api m 21 kitabsoluteantibodyBAB2Anti-Bet v 1 1 kitabsoluteantibodyBAB3Anti-Bet v 11 kitabsoluteantibodyBAB4Anti-Bet v 11 kitabsoluteantibodyBAB5Anti-Bet v 1 1 kitabsoluteantibodyBV16Anti-Bet v 1 1 kitabsoluteantibodyM0418Anti-Bet v 11 kitabsoluteantibody4C3Anti-Bla g 2 1 kitabsoluteantibody7C11Anti-Bla g 21 kitabsoluteantibodyD1Anti-Bos d 5 1 kitabsoluteantibody6A8Anti-Der f 11 kitabsoluteantibody10B9Anti-Der p 11 kitabsoluteantibody5H8Anti-Der p 11 kitabsoluteantibody4C1Anti-Neurotoxin AahII1 kitabsoluteantibodyH10Anti-Der p 21 kit
品牌分类
关注表位标记
Primary Antibodies
Recombinant Antibodies from Human Patients
Anti-Allergen Antibodies
多标签控制蛋白
Recombinant Isotype Controls
抗过敏原抗体
重组F4/80克隆CI:A3-1
体内研究用重组抗体
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