![绝对抗体/Ab00448-1.1抗TNF-α[CDP 571（腐殖酸）]/Ab00448-1.1/200µg](https://www.ebiomall.cn/images/absoluteantibody/IMG00031Ab00448-13.0WBfull.png)
绝对抗体/Ab00448-1.1抗TNF-α[CDP 571（腐殖酸）]/Ab00448-1.1/200µg
商品编号：
Ab00448-1.1
品牌：
absoluteantibody
市场价：
¥6384.00
美元价：
3830.40
产品分类：
临床研究
公司分类：
clinical_research
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description: Recombinant monoclonal antibody to TNF alpha. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma CDP 571 (Humicade).
Clone Number: CDP 571 (Humicade)
UniProt Accession Number of Target Protein: P01375
Alternative Name(s) of Target: Tumour necrosis factor superfamily member 2, TNFSF2, TNFA.
Published Application(s): ELISA; NTRL
Published Species Reactivity: Human
Immunogen: Human TNF-alpha
Specificity: The antibody binds to human TNF-alpha with a Kd of 0.087 nM.
Application Notes: The antibody binds specifically to TNF-alpha, a pro-inflammatory cytokine which stimulates release of other cytiokines e.g. IL-1, IL-6 and GM-CSF as well as secretion of ICAM-1 and VCAM-1 from endothelial cells. It stimulates acute phase responses and acts as a chemoattractant for NK cells and monocytes/macrophages. The antibody reached Phase II clinical trials with Celltech, UCB.
Antibody First Published in:
Stephens et al. Comprehensive pharmacokinetics of a humanized antibody and analysis of residual anti-idiotypic responses. Immunology. 1995 Aug;85(4):668-74. PMID:7558164 Note on publication: CDR regions from murine antibody CB0010 specific for TNFalpha were engineered onto human gamma4 and kappa light chains to produce CDP571.
Concentration: See vial label.
Important note – This product is for research use only. It is not intended for use in therapeutic or diagnostic
procedures for humans or animals.NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques.
Species and Isotype: Mouse IgG1, kappaClone Number: CDP 571 (Humicade)
UniProt Accession Number of Target Protein: P01375
Alternative Name(s) of Target: Tumour necrosis factor superfamily member 2, TNFSF2, TNFA.
Published Application(s): ELISA; NTRL
Published Species Reactivity: Human
Immunogen: Human TNF-alpha
Specificity: The antibody binds to human TNF-alpha with a Kd of 0.087 nM.
Application Notes: The antibody binds specifically to TNF-alpha, a pro-inflammatory cytokine which stimulates release of other cytiokines e.g. IL-1, IL-6 and GM-CSF as well as secretion of ICAM-1 and VCAM-1 from endothelial cells. It stimulates acute phase responses and acts as a chemoattractant for NK cells and monocytes/macrophages. The antibody reached Phase II clinical trials with Celltech, UCB.
Antibody First Published in:
Stephens et al. Comprehensive pharmacokinetics of a humanized antibody and analysis of residual anti-idiotypic responses. Immunology. 1995 Aug;85(4):668-74. PMID:7558164 Note on publication: CDR regions from murine antibody CB0010 specific for TNFalpha were engineered onto human gamma4 and kappa light chains to produce CDP571.
Product Form
Purification: Protein A affinity purified Supplied in: PBS only.
Storage Recommendation: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°CConcentration: See vial label.
品牌介绍
Absolute antibody本公司服务于抗体测序、制造和工程服务提供给所有抗体使用者和不断增长的抗体。Absolute Antibody Ltd was founded in Oxford, UK, in August 2012, with the vision that all antibody users should be able to use recombinant antibodies, which are absolutely defined by their amino acid sequence. This view gained support in 2015 with a Comment in Nature magazine by Bradbury and Pluckthun (+110 co-signatories) – “Reproducibility: Standardize antibodies used in research“. Rather than creating entirely new antibodies (or antibody-like molecules), we are building a catalog by taking existing antibodies (often from hybridomas) then manufacturing them in a superior way and improving their usefulness by engineering.品牌货号名称规格absoluteantibody21 E11Anti-Api m 21 kitabsoluteantibodyBAB2Anti-Bet v 1 1 kitabsoluteantibodyBAB3Anti-Bet v 11 kitabsoluteantibodyBAB4Anti-Bet v 11 kitabsoluteantibodyBAB5Anti-Bet v 1 1 kitabsoluteantibodyBV16Anti-Bet v 1 1 kitabsoluteantibodyM0418Anti-Bet v 11 kitabsoluteantibody4C3Anti-Bla g 2 1 kitabsoluteantibody7C11Anti-Bla g 21 kitabsoluteantibodyD1Anti-Bos d 5 1 kitabsoluteantibody6A8Anti-Der f 11 kitabsoluteantibody10B9Anti-Der p 11 kitabsoluteantibody5H8Anti-Der p 11 kitabsoluteantibody4C1Anti-Neurotoxin AahII1 kitabsoluteantibodyH10Anti-Der p 21 kit
品牌分类
关注表位标记
Primary Antibodies
Recombinant Antibodies from Human Patients
Anti-Allergen Antibodies
多标签控制蛋白
Recombinant Isotype Controls
抗过敏原抗体
重组F4/80克隆CI:A3-1
体内研究用重组抗体
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